Redhead pain pathways
Background: Anesthetic requirement in redheads is exaggerated, suggesting that redheads may be especially sensitive to pain. We therefore tested the hypotheses that women with natural red hair are more sensitive to pain, and that redheads are resistant to topical and subcutaneous lidocaine. Data are presented as medians [interquartile ranges]. Results : Current perception, pain perception, and pain tolerance thresholds were similar in the red-haired and dark-haired women at , , and 5 Hz. In contrast, redheads were more sensitive to cold pain perception Subcutaneous, lidocaine was significantly less effective in redheads, e.
Anesthetic Requirement is Increased in Redheads
Why Are Redheads More Sensitive? | Psychology Today
It turns out the genes that produce redheads also lead them to experience pain differently than the rest of us. Redheads are harder to sedate, but they have a different tolerance for pain, says UCI Health pain management specialist Dr. Shalini Shah. Both parents need to pass along a recessive genetic trait for their child to have red hair. They inherit mutations in the melanocortin 1 receptor, or MC1R, on chromosome
Do redheads feel more pain?
Response to painful stimuli is susceptible to genetic variation. Numerous loci have been identified which contribute to this variation, one of which, MC1R , is better known as a gene involved in mammalian hair colour. MC1R is a G protein-coupled receptor expressed in melanocytes and elsewhere and mice lacking MC1R have yellow hair, whilst humans with variant MC1R protein have red hair. Previous work has found differences in acute pain perception, and response to analgesia in mice and humans with mutations or variants in MC1R. We have tested responses to noxious and non-noxious stimuli in mutant mice which lack MC1R, or which overexpress an endogenous antagonist of the receptor, as well as controls.
Redheads feel more pain, studies have shown. At least, a different kind of pain. To say that redheads have their own charm would be an understatement, but it has also had its downsides — particularly during the Dark Ages , when gingers were often considered witches or heretics. Red hair is most commonly found in the northern and western parts of Europe, especially in and around the British Isles. Still, even so, red is, by a wide margin, the rarest natural hair color.